ECR 2013 Rec: Crohn’s disease activity: correlation of inflammatory mediators with overall small-bowel motility #B0198 #SS201a

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B-0198 Crohn’s disease activity: correlation of inflammatory mediators with overall small-bowel motility

S. Bickelhaupt, S. Pazahr, J.M. Froehlich, R. Cattin, H. Bouquet, G. Rogler, P. Frei, A. Boss, M. Patak | Thursday, March 7, 14:00 – 15:30 / Room E2

Purpose: Active Crohn’s disease (CD) increases the level of inflammatory markers of which C-reactive protein (CRP) and calprotectin are commonly used to monitor disease activity. The aim was to evaluate the correlation between CRP and calprotectin levels and overall small bowel motility in patients with Crohn’s disease assessed with MRI.

Methods and Materials: 13 patients with Crohn’s disease (4f/9m, mean 42y) were included in this IRB-approved prospective study. MRI (1.5-T, Philips Achieva) was performed after a 1-h preparation of 1000 ml Mannitol-Solution (3%). Cine T2w-2D-SSFP motility acquisitions (TR 2.47/TE 1.23/250ms slice repetition time) were performed in free breathing over 69-84sec. Randomly chosen small-bowel segments were analysed in two abdominal quadrants using dedicated MR-motility assessment software (Motasso). Contraction frequency, amplitude, luminal diameter and amplitude diameter ratio (occlusion ratio, ADR) were evaluated as well as CRP (ngl/ul) and Calprotectin (ug/g) levels. Pearson’s correlation was calculated.

Results: Calprotectin was determined in mean 12 days (SEM±10.09) before, CRP 15 days (SD±28.80) before MRI. A significant inverse linear correlation was found between the contraction frequency and both the level of CRP (r=-0.701, p=0.008) and calprotectin (r=-0.805, p=0.001). Expansion of the mean small bowel diameter significantly correlated with calprotectin levels (r=0.857, p=<0.001) but not with CRP (r=0.447, p=0.126). The absolute amplitude of the contractions did not correlate neither with the level of CRP (r=-0.527, p=0.064) nor with calprotectin (r=-0.612, p=0.026). The ratio describing relative luminal occlusion during contraction (ADR) significantly correlated with calprotectin (r=0.736, p=0.004) and with CRP (r=0.577, p=0.039).

Conclusion: Alterations of overall small bowel motility during active phases of CD significantly correlate with the level of calprotectin and CRP.

 

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08
Jul 2013
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