José Vilar and Friends Case 27

Hello friends,

I hope you are doing well wherever you are. Here things are not too good but for the moment I am well.

Here is a case just brought from Dr Peset University Hospital in Valencia.

71 year old man who had a syncope and is brought to the Emergency Room. The COVID 19 ARN (RT-PCR) is negative.

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30
Mar 2020
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ACE2 – A rational frontline therapy for COVID-19 summary

On Thursday March 12th, our ESR Connect studio was the epicenter of an important discussion on COVID-19 as we had the privilege to host professor Josef Penninger, world-leading geneticist and immunologist. Prof. Penninger delivered a compelling and important lecture on ACE2 and its role in the ongoing COVID-19 pandemic.

The lecture focused on the discovery and importance of angiotensin converting enzyme 2 (ACE2). Found in many organs, ACE2 positively affects blood pressure, kidney diseases, liver/lung fibrosis, and many other conditions. ACE creates angiotensin II which triggers angiotensin receptors AT1R and AT2R. This reaction can lead to lung edema and severe respiratory diseases, unless ACE2 is present. ACE2 molecules inactivate the bond between ACE and AngII and prevent the receptors from getting activated, thus protecting the organism from coming to harm. Read more…

23
Mar 2020
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