B-0950 Clinical feasibility of contrast-enhanced dual-energy mammography (CEDEM) with a tungsten (W)/titanium (Ti) anode/filter combination: a prototype report

T. Knogler, R. Leithner, M. Hörnig, F. Semturs, M. Waitzbauer, G. Langs, P. Homolka, K. Pinker-Domenig, T.H. Helbich | Monday, March 11, 14:00 – 15:30 / Room F1

Purpose: To test the feasibility of CEDEM with a W/Ti anode/filter combination for high energy images in a clinical setting.
Methods and Materials: Fifteen female patients with 15 breast lesions were included in this study. CEDEM was performed with a Mammomat Inspiration prototype (Siemens, Germany) before and after i.v. administration of 2-ml Iomeron® 400 (Bracco, Italy) per kg b.w. at a rate of 3.5ml/sec. Dual-energy images were acquired with 28-32kVp and a W/Rhodium (Rh) anode/filter combination for low-energy and 49 kVp and a W/Ti anode filter combination for high energy. Weighted subtraction images were computed for diagnostic work-up. Images were assessed by two readers with respect to lesion-enhancement and image quality. A histological work-up was performed in all lesions.
Results: Histopathology revealed eight malignant lesions and seven benign lesions (size range from 8 to 38mm). All malignant lesions enhanced and were seen from both readers on weighted subtraction images. Benign lesions did not enhance thus they were not visualised on weighted subtraction images. Image quality was rated excellent from both readers. Based on the visibility of the lesion CEDEM allowed an accurate differentiation of benign and malignant breast lesions.
Conclusion: CEDEM with a W/Ti anode/filter combination is suitable and feasible. Lesion visibility and image quality were excellent. Further research is needed to determine the value of CEDEM in a clinical setting.

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