B-0951 Comparison of contrast-enhanced dual-energy mammography (CEDEM) with contrast-enhanced magnetic resonance imaging (CE-MRI) in breast lesions: a prototype report

T. Knogler, R. Leithner, M. Hörnig, M. Waitzbauer, F. Semturs, G. Langs, P. Homolka, K. Pinker-Domenig, T.H. Helbich | Monday, March 11, 14:00 – 15:30 / Room F1

Purpose: To test the feasibility of CEDEM, by comparing its results with CE-MRI in breast lesions.
Methods and Materials: Fifteen female patients with 15 breast lesions were included in this study. CEDEM was performed with a Mammomat Inspiration prototype (Siemens, Germany) before and after i.v. administration of 2 ml Iomeron® 400 (Bracco, Italy) per kg b.w. at a rate of 3.5ml/sec. The same lesions were assessed with CE-MRI (Tim Trio, Siemens, Erlangen, Germany) using a standard protocol and the administration of 0.2mmol Dotarem® (Guerbet, France) per kg b.w. Images of both modalities were assessed by two readers with respect to morphology and enhancement characteristics. A histological work-up was performed in all lesions.
Results: Histopathology revealed eight malignant and seven benign lesions (size range from 8 to 38mm). Morphology and enhancement characteristics were similar and comparable with both techniques. All malignant lesions showed strong contrast uptake and suspicious morphologic signs, whereas benign lesions tend to enhance less strong on both techniques. Based on the morphologic and enhancement characteristics CEDEM and CE-MRI allowed accurate differentiation of benign and malignant breast lesions.
Conclusion: CEDEM allows adequate differentiation of benign and malignant breast lesions using morphologic and enhancement characteristics. CEDEM imaging features are comparable to those of CE-MRI. CEDEM offers a feasible and low cost alternative to CE-MRI in breast lesions.

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