ECR 2013 Rec: Feasibility of abdominal diffusion Kurtosis imaging compared to standard diffusion weighted imaging at 1.5 and 3 Tesla #SS1701b #B0829
B-0829 Feasibility of abdominal diffusion Kurtosis imaging compared to standard diffusion weighted imaging at 1.5 and 3 Tesla
H. Haubenreisser, J. Hansmann, A. Lemke, J. Wambsganss, S.O. Schönberg, U. Attenberger | Monday, March 11, 10:30 – 12:00 / Room I/K
Purpose: To demonstrate the feasibility of diffusion kurtosis imaging (DKI) for the depiction and differentiation of liver and kidney abnormalities in comparison to standard diffusion weighted imaging (DWI) at 1.5 and 3 T.
Methods and Materials: 109 consecutive patients underwent a routine abdominal MR protocol including standard DWI and DKI. 1.5 and 3 T b-values for DKI were identical: b=0-100-500-1000-1500-2000 s/mm². 55 liver and 36 kidney lesions were evaluated at 1.5 T, and 16 liver and 11 kidney lesions, respectively, at 3 T. DKI was assessed by an in-house built software. Kurtosis values were quantified by region-of-interest analysis and compared between lesions and normal parenchyma by a Wilcoxon rank sum test.
Results: Mean kidney kurtosis values were identical at 1.5 and 3 T in normal parenchyma (K=0.5) and cysts (K=0.4). Differences dependent on field strength were only found in malignant tumours (0.8 vs 0.5). At 1.5 as well as 3 T, cysts, tumours and normal kidney parenchyma could be differentiated with significance (p<0.0413) using the kurtosis values. At both field strengths, cysts, benign and malignant liver tumours could be differentiated with statistical significance from normal parenchyma (p<0.001, p<0.0071, p<0.001). However, malignant and benign liver tumours were significantly different at 1.5 T (p=0.0382). Abnormalities and normal parenchyma could be visually differentiated on both, DWI and DKI.
Conclusion: DKI of kidney and liver abnormalities is feasible at both, 1.5 and 3 T and allows for a quantified differentiation between normal parenchyma and pathologic lesions.
